Deploying from Sandbox - Loss of Permissions, Page Assignments, Field Security etc. When you add profiles to assign permissions in a change set, it only impacts the components of the change set. Change sets are never destructive, so they can't remove permissions you've assigned in production. You are safe to include the profiles during the change set deploy. Just be aware some Profile settings are always transferred when you include the profile in the change set (e.g. Profile's system permissions). To avoid overwriting the production profile settings from sandbox, simple solution is to first send change set with anything (e.g. Account custom field) which is the same on prod and sandbox + all profiles from prod to sandbox - this will apply the production permissions to sandbox - and then you can send your change set from sandbox to prod. As sandbox has already been updated to prod status, you won't overwrite anything and only add new stuff to the profiles on pro